Traditional wound healing is often ineffective for diabetic or immunocompromised patients. This research investigates using a non-thermal plasma discharge to “spray” a nebulized collagen solution directly onto wounds, creating a dry and adherent bioactive coating.
Key Findings
-
Structural Integrity: Surface analysis (XPS, FTIR) confirmed that the plasma process successfully deposited the collagen without destroying its essential chemical and biological properties.
-
Accelerated Healing: In a diabetic rabbit model, wounds treated with the plasma-collagen combination healed significantly faster than untreated controls.
-
Enhanced Results: While plasma treatment alone helped reduce inflammation, adding the collagen component led to a statistically significant (p < 0.05) increase in angiogenesis (new blood vessel formation) and overall closure rates.
